RAF1 and myeloid leukemia: Ibrado et al (1997) reported that taxol-induced apoptosis in HL-60 human myeloid leukaemia cells was not associated with activation of Raf-1. Our finding that activated Ras, which acts upstream of Raf-1, failed to induce taxotere sensitivity, suggest that involvement of Raf-1 kinase in taxotere-induced apoptotic signaling pathways is unlikely in v-src-transfected HAG-1 cells.