We have previously demonstrated that one of these inhibitors, ZM 252868 (PD 153035, 4(3-bromoanilino)-6,7-dimethoxyquinazoline) inhibited ovarian cancer cell growth and tyrosine phosphorylation on the EGFR (Simpson et al, 1999), however this compound was ineffective in vivo (Kunkel et al, 1995). The gene discussed is EGFR; the disease is ovarian carcinoma.