These values represented a statistically-significant higher level of S100A4 mRNA in the liver metastases than in the primary cancer specimens (Figures 2B and 3E,F) when analyzed either as two groups (P<0.001, two-tailed Mann–Whitney U-Test) or as matched pairs (P<0.015, Wilcoxon Signed Rank Pairs test). Here, S100A4 is linked to cancer.