PLG and neoplasm: If one assumes that active coagulation also occurs extravascularly and contributes to stromal remodelling, then the observed correlations between the cytokine levels, fibrin split products and tumour kinetics, suggest that as new microvessels develop, they are rendered more permeable for large molecules by VEGF, either locally produced or delivered by platelets, enabling a shift towards the extravascular compartment of plasma molecules like plasminogen and fibrinogen.