Figure 2 shows Kaplan–Meier survival plots generated on the basis of low and high VEGF expression (Figure 2B). No statistical association was found between p53 alterations and overall survival. In fact, tumours expressing p53 protein failed to influence the clinical behaviour of the disease (P=0.1). Furthermore, no association was found between p53 alterations, vascular count and VEGF expression (P=0.6; P=0.8) (data not shown). The gene discussed is VEGFA; the disease is neoplasm.