Indeed, genetic alteration of p53 or p53 protein over-expression has already been reported to be a good predictor for treatment response and survival in oesophageal cancer (Sarbia et al, 1994; Nabeya et al, 1995; Casson et al, 1998; Ribeiro et al, 1998; Yang et al, 1999; Kobayashi et al, 1999; Shimada et al, 2000). This evidence concerns the gene TP53 and carcinoma of esophagus.