Thus, the densities of IL-8 positive foci and vascular hot spots were higher in metastatic than in non-metastatic primary tumours in untreated mice, and treatment with neutralizing antibody against VEGF, IL-8, or VEGF and IL-8 reduced the incidence of metastases and the density of vascular hot spots comparatively. Here, CXCL8 is linked to neoplasm.