CXCL8 and neoplasm: The primary tumours were removed when the largest diameter had attained approximately 10 mm and the following parameters were determined and related to the metastatic status of the hosts: hypoxic fraction, density of hypoxic foci, normoxic fraction, necrotic fraction, IL-8 positive fraction, density of IL-8 positive foci, hot spot microvessel density and density of vascular hot spots.