ESR2 and breast cancer: It is notable that mRNAs corresponding to alternatively spliced forms of ERβ have been detected in breast cancer tissues and cell lines (Lu et al, 1998; Moore et al, 1998; Vladusic et al, 1998; Iwao et al, 2000) as well as in normal human tissues (Ogawa et al, 1998b; Scobie et al, 2001).