SELE and cancer: Phillips et al (1990) demonstrated that anti-sLx CSLEX mAb blocked adhesion of a human promyelocytic cell line to human endothelial cells. These results indicated the complexity of expression and function of sLx and sLa epitopes on the established cell lines. However, it is conceivable that down regulation of E-selectin, a ligand for sLx and sLa antigens, by cimetidine can block some of the malignant phenotype of cancer as predicted by our recent study (Kobayashi et al, 2000).