There is a strong inverse correlation between the Snail and E-cad expression in a panel of epithelial and dedifferentiated cells derived from carcinomas of various etiologies, including oral squamous carcinoma, breast, pancreas, colon, bladder cancer, melanomas, and fibroblast (Batlle et al, 2000; Cano et al, 2000; Yokoyama et al, 2001). This evidence concerns the gene CDH1 and carcinoma.