From the standpoint of hepatocellular carcinogenesis, unveil the mechanism of functions and regulation of Snail are not only important for understanding of hepatocarcinogenesis and intrahepatic metastasis processes, but will facilitate the design of novel therapies for HCC and the control of biologic responses after surgery (Guyton and Kensler, 1997; Hayashi et al, 1999). Here, SNAI1 is linked to hepatocellular carcinoma.