A total of 25 patients with systemic and 16 with regional metastatic melanoma were analysed before initiation of biochemotherapy (cis-platinum 30 mg/m2 d.1–3, DTIC 250 mg/m2 d.1–3 i.v. and IFN-α2b 10 million IU s.c. 3 days a week, q. Here, IFNA2 is linked to metastatic melanoma.