TP53 and Burkitt lymphoma: A common denominator among all these diseases is the consistent presence of chromosomal translocation leading to c-myc activation.6 On the other hand, environmental factors or lifestyle acts on the molecular subtypes of Burkitt's lymphoma.30 It may possible that ethnic and/or geographical factors might account for different frequencies of p53 alterations between Brazilian Burkitt's lymphoma and sporadic Burkitt's lymphoma patients from others countries.