Indeed, we previously reported that the male subjects with fractional excretion of β2-microglobulin (FE β2-m) exceeding 10%, who were included in the present study, were at risk for development of osteomalacia, and those with FE β2-m level exceeding 30% manifested generalized proximal tubular dysfunction clinically as well as females27). The gene discussed is HLA-G; the disease is osteomalacia.