The higher levels of bcl-2 immunostaining generally seen here in association with more advanced Gleason grade and metastatic disease suggest that an increase in the ratio of these anti-apoptotic proteins often occurs during progression of prostate cancers.1 The intensity of bcl-2 immunostaining and the percentage of immunopositive cells are generally higher in the more advanced tumors, largely accounting for the higher composite scores.1 This evidence concerns the gene BCL2 and prostate cancer.