Consistent with the murine orthologue,apM1 mRNA was expressed in culturedhuman adipocytes and not in preadipocytes.Using RT-PCR we confirmed that apM1 mRNAlevels were significantly reduced in omental adiposetissue of obese patients with Type 2 diabetes comparedwith lean and obese normoglycemic subjects.Although less pronounced, apM1 mRNA levelswere reduced in subcutaneous adipose tissue ofType 2 diabetic patients. This evidence concerns the gene ADIPOQ and type 2 diabetes mellitus.