The nephrotic syndrome may lead to hypercoagulability as a consequence of the alteration in the level of coagulation factors, including a decrease in factors IX, X, and XII; elevation especially of the levels of the factors V and VIII, fibrinogen, beta-thromboglobulin and platelets; decrease in coagulation inhibitors, such as proteins C and S and ATIII; and increase in platelet aggregation. The gene discussed is PPBP; the disease is nephrotic syndrome.