RARA and acute promyelocytic leukemia: Results from randomized studies comparing chemotherapy alone to allogeneic and autologous bone marrow transplantation have become available.7-11 Better results are seen in APL, a distinct subtype of AML, in which a balanced reciprocal translocation between chromosomes 15 and 17 results in the union of portions of the promyelocytic leukemia gene with the gene for retinoic acid receptor alpha.