In the CD4+TIL from the 20 patients with RCC, levels of mRNAs encoding for IFN-γ (P≤ 0.001), IL-10 (P≤ 0.05), and FasL (P≤ 0.001) were significantly higher than in the autologous CD4+PBL. This evidence concerns the gene CD4 and renal cell carcinoma.