To investigate the relationship between the expression of p21WAF1/ClP1protein and p53 status and the possible role of the two proteins in hepatocellular carcinomas (HCCs), we examined the expression of p21WAF1/CIP1and p53 immunohistochemically in 81 tumours from 65 patients with hepatocellular carcinoma. Here, TP53 is linked to neoplasm.