The 5-year metastasis-free survival-rate for patients with tumour size ≤5 cm + MIB-1 <10% was 0.83 (95% confidence interval (CI) 0.64–0.92) compared to 0.31 (95% CI 0.11–0.53) in cases with tumour size >5 cm + MIB-1 ≥10%. This evidence concerns the gene MIB1 and neoplasm.