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Simple chained guide trees give poorer multiple sequence alignments than inferred trees in simulation and phylogenetic benchmarks.

(PMID:25564672 PMCID:PMC4299236)
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Affiliations
  • 1. Faculty of Medicine, Department of Molecular Sciences, Institute of Clinical Sciences, Imperial College London, London W12 0NN, United Kingdom; Computational Regulatory Genomics, Medical Research Council Clinical Sciences Centre, London W12 0NN, United Kingdom;
  • 2. Institute of Molecular Life Sciences, University of Zurich, 8057 Zurich, Switzerland; Swiss Institute of Bioinformatics, 8092 Zurich, Switzerland;
  • 3. Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland;
  • 4. European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, United Kingdom; and.
  • 5. European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, United Kingdom; and Department of Genetics, Evolution & Environment and Department of Computer Science, University College London, London WC1E 6BT, United Kingdom c.dessimoz@ucl.ac.uk.
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Proceedings of the National Academy of Sciences of the United States of America [06 Jan 2015, 112(2):E99-100]
Type: Letter, Comment
DOI: 10.1073/pnas.1417526112 The Digital Object Identifier (DOI) System enables identification of digital entities

A comment on this article appears in "Reply to Tan et al.: Differences between real and simulated proteins in multiple sequence alignments." Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):E101.

This is a comment on "Simple chained guide trees give high-quality protein multiple sequence alignments." Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10556-61.

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