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The evolution of enzyme function in the isomerases.

(PMID:25000289 PMCID:PMC4139412)
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Affiliations
  • 1. European Molecular Biology Laboratory, European Bioinformatics Institute EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, United Kingdom. Electronic address: scuesta@ebi.ac.uk.
  • 2. Department of Pathogen Molecular Biology, London School of Hygiene & Tropical Medicine, Keppel Street, London, WC1E 7HT, United Kingdom.
  • 3. European Molecular Biology Laboratory, European Bioinformatics Institute EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, United Kingdom.
  • 4. Institute of Structural and Molecular Biology, Division of Biosciences, University College London, Gower Street, London, WC1E 6BT, United Kingdom.
  • 5. European Molecular Biology Laboratory, European Bioinformatics Institute EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, United Kingdom. Electronic address: thornton@ebi.ac.uk.
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Current Opinion in Structural Biology [01 Jun 2014, 26:121-130]
Type: Research Support, Non-U.S. Gov't, review-article, Review, Journal Article
DOI: 10.1016/j.sbi.2014.06.002 The Digital Object Identifier (DOI) System enables identification of digital entities

Abstract

The advent of computational approaches to measure functional similarity between enzymes adds a new dimension to existing evolutionary studies based on sequence and structure. This paper reviews research efforts aiming to understand the evolution of enzyme function in superfamilies, presenting a novel strategy to provide an overview of the evolution of enzymes belonging to an individual EC class, using the isomerases as an exemplar.
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